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IRG1 (ACOD1) (NM_001258406) Human Tagged Lenti ORF Clone

  • LentiORF®
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SKU
RC232825L4
Lenti ORF clone of Human aconitate decarboxylase 1 (ACOD1), mGFP tagged
ORF Plasmid:
mGFP DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
  $1,032.00
3 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol IRG1
Synonyms CAD; IRG1
Vector pLenti-C-mGFP-P2A-Puro
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC232825).
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_001258406
ORF Size 1443 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001258406.1, NP_001245335.1
RefSeq Size 2111 bp
RefSeq ORF 1446 bp
Locus ID 730249
UniProt ID A6NK06
Cytogenetics 13q22.3
MW 53.1 kDa
Summary Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.UniProtKB/Swiss-Prot Function
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"NM_001258406" in other vectors (6)
SKU Description Size Price
RC232825 ACOD1 (Myc-DDK tagged) - Human aconitate decarboxylase 1 (ACOD1) 10 ug
$289.00 $732.00
RC232825L1 Lenti ORF clone of Human aconitate decarboxylase 1 (ACOD1), Myc-DDK-tagged 10 ug
$1,032.00
RC232825L2 Lenti ORF clone of Human aconitate decarboxylase 1 (ACOD1), mGFP tagged 10 ug
$1,032.00
RC232825L3 Lenti ORF clone of Human aconitate decarboxylase 1 (ACOD1), Myc-DDK-tagged 10 ug
$1,032.00
RG232825 ACOD1 (tGFP-tagged) - Human aconitate decarboxylase 1 (ACOD1) 10 ug
$489.00 $932.00
SC330681 ACOD1 (untagged) - Human aconitate decarboxylase 1 (ACOD1) 10 ug
$503.00

Plasmid Map for RC232825L4

Download sequence for

file-download TXT (FASTA format)

file-download Genbank

Cloning scheme for RC232825L4
Circular map for RC232825L4

file-alt Citations

ZFTA-RELA ependymomas make itaconate to epigenetically drive fusion expression
Natarajan, Lum, Skeans et al
Nature (2026)
Cited by 9
AI Summary: OriGene contributed to this study by providing the human ACOD1 lentiviral cDNA (SKU RC232825L4) and scrambled vector controls, which were used to investigate the role of ACOD1 in itaconate production and ZFTA-RELA expression in ependymoma cells.
Snippet: Human ACOD1 lentiviral cDNA (NM_001258406) and scrambled vector controls were purchased from Origene (SKU RC232825L4)
Showing 1-1 of 1 papers.
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