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pCMV6-XL6 Mammalian Expression Vector

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SKU
PCMV6XL6
Cloning vector pCMV6-XL6, 10 ug circular vector
  $470.00
In Stock*
Specifications
Specifications
Product Data
C-Tag Tag Free
E. coli Selection Ampicillin (100 ug/mL)
Download Vector Sequence
Components 1 vial of 10 ug lyophilized pCMV6-XL6 vector
Quality Control This vector was sequence verified and restriction-digest confirmed.
Storage Store the vector DNA at -20°C.
Stability Vector DNA is stable for at least one year from date of receipt when stored at -20°C.
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Documents
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DnaJB6: A Potent DnaJB Chaperone in Regulating Tau Proteostasis
Esquivel
Thesis (2025)
AI Summary: OriGene products, specifically the pCMV6 vector (#RC223397) and the pCMV6 vector with an N-terminal FLAG tag (#PCMV6XL6), were used as cloning and expression vectors in the study investigating DnaJB6's role in regulating Tau proteostasis.
Snippet: … pCMV6 (Origene, #RC223397), pCMV6 with an N-terminal FLAG tag (Origene, #PCMV6XL6) and pCDNA5 FRT/TO (Invitrogen #V6520-20) empty vectors were purchased from verified sources. …
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion
Terao, Lee, Colasanti et al
Cell Rep (2024)
Cited by 56
AI Summary: OriGene products pCMV6-XL6 and pCMV6-AC-CD38-GFP plasmids were used in this study to manipulate CD38 expression in macrophages, enabling the investigation of molecular mechanisms linking cholesterol metabolism to macrophage senescence and neurodegeneration.
Snippet: pCMV6-XL6 OriGene Technologies Cat#PCMV6XL6 pCMV6-AC-CD38-GFP OriGene Technologies Cat#MG204265
DnaJs are enriched in tau regulators
Esquivel, Hill, Blair
Int J Biol Macromol (2023) 253 (Pt 7), 127486 DOI: 10.1016/j.ijbiomac.2023.127486
Cited by 5
AI Summary: OriGene products pCMV6 (RC223397) and pCMV6 with N-terminal FLAG tag (PCMV6XL6) were used as expression vectors in this study to facilitate the overexpression and functional analysis of candidate chaperone proteins influencing tau pathology.
Snippet: FKBP133 (HsCD00294942) were subcloned from DNASU purchased donor plasmid into the pCMV6 vector. pCMV6 (Origene, #RC223397), pCMV6 with an N-terminal FLAG tag (Origene, #PCMV6XL6) and pCDNA5 FRT/TO (Invitrogen #V6520–20) empty vectors were purchased from verified sources
A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing
Taylor, Wan, Donde et al
Nat Chem (2022) 14 (11), 1295-1305 DOI: 10.1038/s41557-022-01021-z
Cited by 66
AI Summary: OriGene’s human KRAS ORF cDNA clone (plasmid pCMV6-XL6, Cat. No. SC109374) was used as a template to generate full-length KRAS RNA transcripts for in vitro cleavage and gene-silencing experiments in this study.
Snippet: _KRas_ORF”) were using prepared using an SP6 transcription kit (NEB, USA) according to the manufacturer’s instructions, using a human KRAS ORF cDNA clone (in plasmid pCMV6-XL6)(Cat. … SC109374, Origene, USA) linearized with XmaI (NEB, USA) as template, and a FITC-AG transcription starter (IBA Life Sciences, Germany). Mutations c.35G>A [G12D] or c.38G>A [G13D] were introduced into the KRAS pl;Long (2.1 kb) 5′-fluorophore-labelled RNAs encoding the complete (wild-type) KRAS ORF and UTRs (‘Sub_KRas_ORF’) were prepared using an SP6 transcription kit (NEB) according to the manufacturer’s instructions, using a human KRAS ORF cDNA clone (in plasmid pCMV6-XL6;cat. … SC109374, Origene) linearized with XmaI (NEB) as template, and a FITC-AG transcription starter (IBA Life Sciences). …
Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma
Vichaikul, Gurrea-Rubio, Amin et al
JCI Insight (2022) 7 (9) DOI: 10.1172/jci.insight.150871
Cited by 27
AI Summary: OriGene’s CAMK2A expression vector and the PCMV6-XL6 control vector were used to overexpress and control for CAMK2A in patient-derived fibroblasts, enabling the study of calcium signaling in the anti-fibrotic effects of BET inhibition in scleroderma models.
Snippet: …CAMK2A in dcSSc fibroblasts was overexpressed using CAMK2A vectors from OriGene. CAMK2A vector (0.1 μg/mL) was mixed with Lipofectamine 2000 (Invitrogen) and then added to culture medium. … PCMV6-XL6 vector (OriGene) w;- using CAMK2A vectors from Origene. 0.1 μg/ml of CAMK2A vector was PCMV6-XL6 vector (Origene) was used as a negative control. …
Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: Implications for drug discovery
Tasma, Siow, Harris et al
Br J Pharmacol (2021)
Cited by 38
AI Summary: OriGene contributed to this study by providing the human PAC1s receptor plasmid (#SC3259542), which was used to investigate the signalling and pharmacological profiles of PACAP-responsive receptors.
Snippet: The human PAC1s receptor was purchased from Origene (#SC3259542, variant 4, Rockville, MD, USA) in the pCMV6XL6 vector, which was then cloned into pcDNA3.1- using the Not I and Hind III restriction sites. All plasmid inserts were sequenced at the Centre
Showing 1-6 of 42 papers.
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