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Sirt5 Rat shRNA Plasmid (Locus ID 306840)

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SKU
TR700596
Sirt5 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 306840
Synonyms MGC93823
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Sirt5 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 306840). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001004256, NM_001004256.1, BC078958
UniProt ID Q68FX9
Summary NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway
Sun, Wang, Gai et al
Front Oncol (2019) 9, 754 DOI: 10.3389/fonc.2019.00754
AI Summary: OriGene products, specifically the SIRT5 expression plasmid and the corresponding empty plasmid, were used to overexpress SIRT5 and as a negative control, respectively, enabling the study of SIRT5’s role in cisplatin resistance in ovarian cancer cells.
Snippet: manufacturer's instructions. A SIRT5 expression plasmid (OriGene, Rockville, MD, USA) and the corresponding empty plasmid (OriGene) were used for SIRT5 overexpression and as a negative control, respectively. Cells were Cached
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Showing 1-1 of 1 papers.
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