Inhba Mouse shRNA Plasmid (Locus ID 16323)
SKU
TR516955
Inhba - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 16323 |
|---|---|
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Inhba - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 16323). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC053527, NM_008380, NM_008380.1, NM_008380.2 |
| UniProt ID | Q04998 |
| Summary | This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. provided by RefSeq, Aug 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma
Taniguchi, Matsui, Kimura et al
Nat Commun (2023) 14 (1), 143 DOI: 10.1038/s41467-022-35701-8
Taniguchi, Matsui, Kimura et al
Nat Commun (2023) 14 (1), 143 DOI: 10.1038/s41467-022-35701-8
Cited by 38
AI Summary: In this study, OriGene’s INHBA (NM_002192) qPCR primers and INHBA shRNA lentiviral particles were used to measure and manipulate INHBA expression in alveolar macrophages, helping to elucidate their role in promoting lung cancer cell proliferation.
Snippet: Alveolar macrophages (AMs) are crucial for maintaining normal lung function. They are abundant in lung cancer tissues, but their pathophysiological significance remains unknown. Here we show, using an orthotopic murine lung cancer model and human carcinoma samples, that AMs support cancer cell proliferation and thus contribute to unfavourable outcome. Inhibin beta A (INHBA) expression is upregulat...
Showing 1-1 of 1 papers.
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