Tbc1d23 Mouse shRNA Plasmid (Locus ID 67581)
SKU
TR503947
Tbc1d23 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 67581 |
|---|---|
| Synonyms | 4930451A13Rik; AU015720; AU043671; AU043778; D030022P07Rik; W51689 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Tbc1d23 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 67581). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC031706, NM_026254, NM_001358433, NM_001358434, NM_026254.1, NM_026254.2, BC019762 |
| UniProt ID | Q8K0F1 |
| Summary | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development
Ivanova, Mau-Them, Riazuddin et al
Am. J. Hum. Genet. (2017)
Ivanova, Mau-Them, Riazuddin et al
Am. J. Hum. Genet. (2017)
AI Summary: OriGene contributed three different 29-mer shRNA plasmids targeting mouse Tbc1d23, which were used to downregulate Tbc1d23 expression and study its role in cortical neuron positioning in this research.
Snippet: … Three different 29-mer shRNA sequences targeting mouse Tbc1d23 (GenBank: NM_026254) commercially designed and provided by Origene were cloned in the psiStrike vector under the control of a U6 promoter: shRNA-1, targeting the sequence ...;... … Three different 29-mer shRNA sequences targeting mouse Tbc1d23 (GenBank: NM_026254) commercially designed and provided by Origene were cloned in the psiStrike vector under the control of a U6 promoter: shRNA-1, targeting the sequence
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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