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CSK Human shRNA Plasmid Kit (Locus ID 1445)

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SKU
TR320311
CSK - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 1445
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CSK - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1445). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001127190, NM_004383, NM_001354988, NM_004383.1, NM_004383.2, NM_001127190.1, BC106073, BC106073.1, BC104847, BC104875, NM_001127190.2
UniProt ID P41240
Summary The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines
Zhang, Kalyankrishna, Wislez et al
Am J Pathol (2007) 170 (1), 366-76 DOI: 10.2353/ajpath.2007.060706
Cited by 156
AI Summary: OriGene’s c-Src short hairpin RNA (shRNA) was used in this study to specifically knock down c-Src expression in HCC827 non-small cell lung cancer cells, enabling the authors to demonstrate that reduced c-Src levels diminish EGFR and ErbB2 phosphorylation and sensitize cells to apoptosis induced by kinase inhibitors.
FigureFigureFigure
Showing 1-1 of 1 papers.
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