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HMGA2 Human shRNA Plasmid Kit (Locus ID 8091)

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SKU
TR319507
HMGA2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 8091
Synonyms BABL; BABL, LIPO, HMGIC, HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; high mobility group AT-hook 2; HMGI-C; HMGIC; LIPO; STQTL9
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components HMGA2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8091). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001015886, NM_001300918, NM_001300919, NM_001330190, NM_003483, NM_003484, NM_003483.1, NM_003483.2, NM_003483.3, NM_003483.4, NM_003484.1, NM_001300918.1, NM_001300919.1, NM_001015886.1, BC160115, BM782659, NM_003483.6
UniProt ID P52926
Summary This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Chaperoning HMGA2 Protein Protects Stalled Replication Forks in Stem and Cancer Cells
Yu, Lim, Tjokro et al
Cell Rep (2014)
Cited by 56
AI Summary: OriGene’s pTRIPz-shHMGA2 lentiviral vector was used to generate recombinant HT1080 cell lines with HMGA2 knockdown, enabling the study of HMGA2’s role in protecting stalled replication forks in stem and cancer cells.
Snippet: Recombinant HT1080-C1 and HT1080-C2 cell lines were generated from individual colonies after lentiviral transduction of HT1080 cells with pTRIPz-shHMGA2 (Origene), followed by puromycin selection. HMGA2-expressing and mock UTC8505 transfectants were generated as previously described
Showing 1-1 of 1 papers.
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