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CISH Human shRNA Plasmid Kit (Locus ID 1154)

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SKU
TR316498
CISH - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 1154
Synonyms BACTS2; CIS; CIS-1; G18; SOCS
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CISH - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1154). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_013324, NM_145071, NM_145071.1, NM_013324.2, NM_013324.3, NM_013324.4, NM_013324.5, BC031590, BC031590.1, BC064354, NM_013324.6, NM_145071.4
UniProt ID Q9NSE2
Summary The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Aug 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge
Hu, Zhou, Liu et al
J Immunol (2009) 183 (3), 1617-24 DOI: 10.4049/jimmunol.0804362
Cited by 122
AI Summary: OriGene products contributed to this study by providing the CIS overexpression plasmid (RC208447) and CIS-specific siRNA (SR304009), which were used for gain- and loss-of-function experiments to investigate the role of CIS in cholangiocyte immune responses.
FigureFigure
Showing 1-1 of 1 papers.
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