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IRF7 Human shRNA Plasmid Kit (Locus ID 3665)

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SKU
TR315487
IRF7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 3665
Synonyms IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IRF7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3665). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001572, NM_004029, NM_004030, NM_004031, NM_004029.1, NM_004029.2, NM_001572.1, NM_001572.2, NM_001572.3, NM_004031.1, BC136555, BC144242, BM849172, NM_004029.4, NM_001572.5
UniProt ID Q92985
Summary IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Mechanistic analysis of an IRF7-dependent pathway in virus-induced fibrosis in chronic lung allograft dysfunction
Banday, Rahman, Goda et al
EBioMedicine (2026) 128, 106285 DOI: 10.1016/j.ebiom.2026.106285
Cited by 1
AI Summary: OriGene's IRF7 shRNA plasmid complete kit (cat. TR315487) was used to suppress IRF7 expression in human precision-cut lung slice (PCLS) models, enabling the study of IRF7's role in virus-induced airway fibrosis in chronic lung allograft dysfunction.
Snippet: … IRF7 shRNA plasmid complete kit (Origene, cat. TR315487) was used to suppress IRF7 expression in PCLS and were transfected with either IRF7-specific or control shRNA plasmid in the absence of antibiotics in the culture media. After 3;- IRF7 shRNA plasmid complete kit (Origene, cat. TR315487) was used to suppress IRF7 expression in PCLS and were transfected with either IRF7-specific or control
FigureFigureFigure
Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro
Minter, Main, Brody et al
J Neuroinflammation (2015) 12 (1), 71 DOI: 10.1186/s12974-015-0263-2
Cited by 35
AI Summary: OriGene's IRF7 shRNA plasmid constructs were used to generate IRF7 knockdown M17 neuroblastoma cell lines, enabling the study to assess the role of IRF7 in neuronal type-1 interferon responses to amyloid exposure.
Snippet: Generation of M17 IRF7 knockdown cell line. IRF7 knockdown (IRF7 KD) and negative control (NC) knockdown M17 cells were generated using commercially available small hairpin RNA (shRNA) plasmid constructs (Origene, Rockville, MD, USA). ... Cite SaveSaving
FigureFigureFigure
Translational control of the innate immune response through IRF-7
Colina, Costa-Mattioli, Dowling et al
Nature (2008) 452 (7185), 323-8 DOI: 10.1038/nature06730
Cited by 316
AI Summary: In this study, OriGene’s IRF7 cDNA clone (Cat# MC202446) was used to investigate the translational regulation of IRF7, contributing to the understanding of how IRF7 mRNA translation affects type-I interferon production in the innate immune response.
Showing 1-3 of 3 papers.
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