IRF7 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human IRF7. The immunogen is located within amino acids 420 - 470 of IRF7. |
| Buffer | PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | interferon regulatory factor 7 |
| Database Link | |
| Background | Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established. |
| Synonyms | IMD39; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins, Transciption Factors |
| Protein Families | Transcription Factors |
| Protein Pathways | Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling
Desnues, Macedo, Ordoñez-Rueda et al
Eur. J. Immunol. (2016)
Desnues, Macedo, Ordoñez-Rueda et al
Eur. J. Immunol. (2016)
Cited by 21
AI Summary: OriGene’s IRF7 antibody was used for immunoblotting to assess IRF7 protein levels, helping the authors investigate how Gfi1 regulates TLR7 signaling pathways in lupus autoimmunity.
Snippet: electrophoresed and transferred onto Immobilon P membrane (Millipore). Blotting was performed using the following antibodies: p65 and phospho-p65 S311 (Santa Cruz), IRF7 (OriGene) and beta-actin (Sigma). The bound antibodies ... Cite SaveSaving
Showing 1-1 of 1 papers.
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