Catalase (CAT) Human shRNA Plasmid Kit (Locus ID 847)
SKU
TR314184
CAT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 847 |
|---|---|
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | CAT - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 847). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001752, NM_001752.1, NM_001752.2, NM_001752.3, BC110398, BC110398.1, BC027300, BC112217, BC112219, NM_001752.4 |
| UniProt ID | P04040 |
| Summary | This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. provided by RefSeq, Oct 2009 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism
Pratheeshkumar, Son, Divya et al
Sci Rep (2016) 6, 37227 DOI: 10.1038/srep37227
Pratheeshkumar, Son, Divya et al
Sci Rep (2016) 6, 37227 DOI: 10.1038/srep37227
AI Summary: OriGene products, specifically the human catalase plasmid and STAT3 shRNA plasmid, were used in this study to manipulate gene expression in bronchial epithelial cells, enabling the researchers to investigate the roles of catalase and STAT3 in arsenic-induced oncogenic transformation.
Snippet: 5% CO2 in air. Plasmids and Transfection Plasmid DNA encoding human catalase and STAT3 shRNA was purchased from Origene (Rockville, MD). PDCD4 3′-UTR reporter plasmid was kindly provided by Dr. Yong Li (U
Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells
Roy, Pratheeshkumar, Son et al
Toxicol. Appl. Pharmacol. (2016) 307, 81-90 DOI: 10.1016/j.taap.2016.07.016
Roy, Pratheeshkumar, Son et al
Toxicol. Appl. Pharmacol. (2016) 307, 81-90 DOI: 10.1016/j.taap.2016.07.016
Cited by 34
Showing 1-2 of 2 papers.
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