CEACAM1 Human shRNA Plasmid Kit (Locus ID 634)
SKU
TR314008
CEACAM1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 634 |
|---|---|
| Synonyms | BGP; BGP1; BGPI |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | CEACAM1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 634). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001024912, NM_001184813, NM_001184815, NM_001184816, NM_001205344, NM_001712, NM_001024912.1, NM_001024912.2, NM_001712.1, NM_001712.2, NM_001712.3, NM_001712.4, NM_001184816.1, NM_001184813.1, NM_001184815.1, NM_001205344.1, BC014473, BC014473.1, BC024164, NM_001184813.2, NM_001205344.2, NM_001184815.2, NM_001712.5, NM_001184816.2 |
| UniProt ID | P13688 |
| Summary | This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. provided by RefSeq, May 2010 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage
Sappino, Buser, Seguin et al
Oncogenesis (2012) 1, e7 DOI: 10.1038/oncsis.2012.7
Sappino, Buser, Seguin et al
Oncogenesis (2012) 1, e7 DOI: 10.1038/oncsis.2012.7
Cited by 28
AI Summary: OriGene’s pRS shRNA constructs targeting CEACAM1 were used to stably silence CEACAM1 expression, enabling the authors to demonstrate its essential role in p53-mediated cellular senescence following DNA damage.
Snippet: silencing using the small hairpin RNA (shRNA) vectors 025, 026 or 028, targeting both the long and short isoforms of ... with stable CEACAM1 silencing were established using shRNA constructs against CEACAM1 in pRS vector purchased from OriGene Technologies/Labforce
Showing 1-1 of 1 papers.
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