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Neutrophil Elastase (ELANE) Human shRNA Plasmid Kit (Locus ID 1991)

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SKU
TR313237
ELANE - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "Neutrophil Elastase or NM_001972"

Specifications
Specifications
Product Data
Locus ID 1991
Synonyms ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components ELANE - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1991). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001972, NM_001972.1, NM_001972.2, NM_001972.3, BC074817, BC074817.2, BC074816, NM_001972.4
UniProt ID P08246
Summary Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. provided by RefSeq, Jan 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
Smith, Mohit, Kenner et al
Cell Commun Signal (2026) 24 (1), 71 DOI: 10.1186/s12964-026-02676-8
Cited by 1
AI Summary: OriGene Technologies contributed to this study by providing three unique human ELANE (neutrophil elastase) shRNA plasmid constructs (Cat# TR313237) and a scrambled control, which were used to knock down ELANE expression in pancreatic cancer cells to investigate its role in immune cell polarization and tumor growth.
Snippet: "Par46">Three unique human shRNA (29mer each) plasmid constructs for human ELANE (neutrophil elastase) in retroviral untagged vector (5 µg each) were purchased from OriGene Technologies (Rockville, MD;Cat# TR313237) along with a scrambled control. The sequences of the shRNAs are shown in Supplementary Table S5. AsPC-1 cells were transfected with Lipofectamine
FigureFigureFigure
Showing 1-1 of 1 papers.
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