IFI16 Human shRNA Plasmid Kit (Locus ID 3428)
SKU
TR312254
IFI16 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 3428 |
|---|---|
| Synonyms | IFNGIP1; PYHIN2 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | IFI16 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3428). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001206567, NM_005531, NM_005531.1, NM_005531.2, NM_001206567.1, BC017059, BM806453, BM993134, NM_001364867, NM_001206567.2 |
| UniProt ID | Q16666 |
| Summary | This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Apr 2011 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells
Bosso, Prelli Bozzo, Hotter et al
PLoS Pathog. (2020) 16 (8), e1008752 DOI: 10.1371/journal.ppat.1008752
Bosso, Prelli Bozzo, Hotter et al
PLoS Pathog. (2020) 16 (8), e1008752 DOI: 10.1371/journal.ppat.1008752
Cited by 39
AI Summary: In this study, OriGene's shRNA mix targeting IFI16 was used to knock down IFI16 expression in human cells, enabling the authors to demonstrate the role of nuclear PYHIN proteins in restricting HIV-1 by interfering with Sp1-dependent gene expression.
Snippet: s (Life Technologies). Cells were cultured in RPMI-1640 medium containing 20% FCS. Three days later, 6*106 cells were transfected with 1.5 μg of shRNA mix against either a control sequence or IFI16 (Origene) using the Amaxa Human T Cell Kit (Lonza), U15 program. Alternatively, 1*106 cells were transfected with the HiFi Cas9 Nuclease V3 (IDT)/gRNA complex (80 pmol/300 pml) (Lonza) using a non-targ
Showing 1-1 of 1 papers.
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