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MDM2 Human shRNA Plasmid Kit (Locus ID 4193)

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SKU
TR311529
MDM2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4193
Synonyms hdm2; HDMX; MGC5370; MGC71221
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MDM2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4193). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001145336, NM_001145337, NM_001145339, NM_001145340, NM_001278462, NM_002392, NM_006878, NM_006879, NM_006880, NM_006881, NM_006882, NM_002392.1, NM_002392.2, NM_002392.3, NM_002392.4, NM_002392.5, NM_001145337.1, NM_001145337.2, NM_001145339.1, NM_001145339.2, NM_001145340.1, NM_001145340.2, NM_001278462.1, NM_001145336.1, NM_006878.2, NM_006879.2, NM_006881.2, NM_006882.2, BC006795, BC065505, BC107414, BC148522, BC152384, BC152390, BC153117, NM_001367990, NM_001145337.3, NM_001145340.3, NM_001278462.2
UniProt ID Q00987
Summary This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. provided by RefSeq, Jun 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Exonuclease-1 interacts with the transcriptional co-repressor KAP1
El-Shemerly, Eid, Hess et al
Matters (2016)
Snippet: Cells were harvested 48h after transfection. For RNA interference experiments, shEV (empty vector pRS), shKAP1 (OriGene Technology) or shMDM2 [49] were transfected in HEK-293T cells to generate stable cell lines, as described [23] . ... Cite SaveSaving
Showing 1-2 of 2 papers.
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