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HDAC8 Human shRNA Plasmid Kit (Locus ID 55869)

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SKU
TR304143
HDAC8 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 55869
Synonyms CDA07; CDLS5; HD8; HDACL1; KDAC8; MRXS6; RPD3; WTS
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components HDAC8 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 55869). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001166418, NM_001166419, NM_001166420, NM_001166422, NM_001166448, NM_018486, NR_051952, NM_018486.1, NM_018486.2, NM_001166448.1, NM_001166420.1, NM_001166422.1, NM_001166419.1, NM_001166418.1, BC050433, NM_001166422.2, NM_001166448.2, NM_001166419.2, NM_001166418.2, NM_018486.3
UniProt ID Q9BY41
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases
Huang, Chen, Chou et al
Mol. Pharmacol. (2011) 79 (1), 197-206 DOI: 10.1124/mol.110.067702
Cited by 111
AI Summary: OriGene products contributed to this study by providing shRNA constructs targeting HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, which were used to investigate the roles of specific HDAC isozymes in regulating histone H3K4 methylation and demethylase expression.
Snippet: suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down-regulation of ... shRNA for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 were purchased from Origene, Inc.
Showing 1-1 of 1 papers.
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