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IL22 Human shRNA Plasmid Kit (Locus ID 50616)

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SKU
TR303948
IL22 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 50616
Synonyms IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa; TIFIL-23; zcyto18
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IL22 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 50616). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_020525, NM_020525.1, NM_020525.2, NM_020525.3, NM_020525.4, BC070261, BC070261.1, BC066263, BC066264, BC066265, BC066266, BC067509, BC067510, BC069112, BC069308, NM_020525.5
UniProt ID Q9GZX6
Summary This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. provided by RefSeq, Jul 2018
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma
Matsuda, Ikeda, Abe et al
Cancer Sci (2022) 113 (4), 1208-1219 DOI: 10.1111/cas.15296
Cited by 17
AI Summary: In this study, OriGene’s Human IL22 shRNA Plasmid (TL313557) and Human IL22 shRNA (Locus ID 50616) were used to knock down IL22 expression in CTCL cells, enabling the researchers to demonstrate the role of IL22 as a direct target of miR-26 in promoting tumor invasion and metastasis.
Snippet: of target messenger RNAs that have specific seed sequences in their 3′ untranslated region (UTR). 16 It has been well documented that, if miRNA is aberrantly expressed, the aberration can induce tumorigenesis via translational repression of target genes and/or their product. 17  We have shown that genomic structural aberration and epigenetic alteration of tumor‐suppressive miRNA may occur in
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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