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MAFA Human shRNA Plasmid Kit (Locus ID 389692)

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SKU
TR303385
MAFA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 389692
Synonyms hMafA; INSDM; RIPE3b1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MAFA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 389692). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_201589, NM_201589.1, NM_201589.2, NM_201589.3, BC156443, NM_201589.4
UniProt ID Q8NHW3
Summary MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 PubMed 12011435).supplied by OMIM, Mar 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells
Lawrence, Naziruddin, Levy et al
J. Biol. Chem. (2011) 286 (2), 1025-36 DOI: 10.1074/jbc.M110.158675
Cited by 17
AI Summary: OriGene products contributed to this study by providing vectors expressing green fluorescent protein (GFP) and mouse MafA shRNA, which were used to investigate the regulatory role of MafA in TNF-α gene expression in pancreatic islet cells.
Snippet: Vectors expressing green fluorescent protein (GFP) and mouse MafA shRNA were obtained from OriGene. ... Therefore, other methods need to be employed to selectively repress cytokine production without affecting islet cell function.
Showing 1-1 of 1 papers.
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