MAFA Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Mouse muscle tissue IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Nucleus |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human MAFA |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | 37 kDa |
| Gene Name | MAF bZIP transcription factor A |
| Database Link | |
| Background | Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. |
| Synonyms | hMafA; RIPE3b1 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Transciption Factors |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
METTL3 promotes human amniotic epithelial stem cells differentiation into insulin-producing cells by regulation of MaFA expression
Luo, Li, Xu et al
Biochim Biophys Acta Mol Basis Dis (2025) 1871 (6), 167904 DOI: 10.1016/j.bbadis.2025.167904
Luo, Li, Xu et al
Biochim Biophys Acta Mol Basis Dis (2025) 1871 (6), 167904 DOI: 10.1016/j.bbadis.2025.167904
Cited by 1
AI Summary: OriGene products—specifically antibodies against METTL3 (TA811770), IGF2BP2 (TA323472), Glut2 (TA381632), PDX1 (TA321081), MaFA (TA367498), and β-actin (TA811000)—were used for protein detection by western blotting and immunofluorescence to assess the differentiation and function of insulin-producing cells in this study.
Snippet: METTL3(1:1000, TA811770, OriGene), IGF2BP2(1:1000, TA323472, OriGene), Glut2(1:1000, TA381632, OriGene), PDX1(1:1000, TA321081, OriGene), MaFA(1:1000, TA367498, OriGene), Insulin(1:1000, ET1601–12, huabio), and β-actin(1:2000, TA811000, OriGene), overnight at 4 °C. After washed with TBST and then incubated with their corresponding HRP-linked secondary antibodies for 1 h at room temperature
Showing 1-1 of 1 papers.
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