MASP2 Human shRNA Plasmid Kit (Locus ID 10747)

SKU TR303337

MASP2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 10747
• Synonyms: MAP-2; MAP19; MASP-2; MASP1P1; sMAP
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: MASP2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 10747). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_006610, NM_139208, NM_006610.1, NM_006610.2, NM_006610.3, NM_139208.1, NM_139208.2, BC052299, BC067359, BC080556, BC156086, BC156886, NM_139208.3, NM_006610.4
• UniProt ID: O00187
• Summary: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient