NOTCH1 Human shRNA Plasmid Kit (Locus ID 4851)
SKU
TR302916
NOTCH1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 4851 |
|---|---|
| Synonyms | AOS5; AOVD1; hN1; TAN1 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | NOTCH1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4851). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_017617, NM_017617.2, NM_017617.3, NM_017617.4, BC013208, BC039147, BC046127, BC049843, BC063597, NM_017617.5 |
| UniProt ID | P46531 |
| Summary | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. provided by RefSeq, Jan 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome
Kobayashi, Yoshida, Tarui et al
PLoS ONE (2014) 9 (7), e102796 DOI: 10.1371/journal.pone.0102796
Kobayashi, Yoshida, Tarui et al
PLoS ONE (2014) 9 (7), e102796 DOI: 10.1371/journal.pone.0102796
Cited by 85
AI Summary: OriGene products, including shRNAs (TR311165B for NKX2-5, TR316857C for HAND1, TR302916D for NOTCH1) and human cDNA clones (SC122690 for HAND1, SC308883 for NOTCH1), were used for gene knockdown and overexpression experiments to investigate the roles of NKX2-5, HAND1, and NOTCH1 in cardiac differentiation and the pathogenesis of hypoplastic left heart syndrome.
Showing 1-1 of 1 papers.
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