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TSC22D1 Human shRNA Plasmid Kit (Locus ID 8848)

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SKU
TR300799
TSC22D1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 8848
Synonyms Ptg-2; TGFB1I4; TSC22
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TSC22D1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8848). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001243797, NM_001243798, NM_001243799, NM_006022, NM_183422, NM_006022.1, NM_006022.2, NM_006022.3, NM_183422.1, NM_183422.2, NM_183422.3, NM_001243799.1, NM_001243797.1, NM_001243798.1, BC000456, BC009528, BC016867, BC069207, BC105277, BC136475, BC136482, BC146664, BC146679, NM_183422.4, NM_006022.4
UniProt ID Q15714
Summary This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, Aug 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Transforming Growth Factor-{beta}-Stimulated Clone-22 Is an Androgen-Regulated Gene That Enhances Apoptosis in Prostate Cancer following Insulin-Like Growth Factor-I Receptor Inhibition
Sprenger, Haugk, Sun et al
Clin Cancer Res (2009) 15 (24), 7634-7641 DOI: 10.1158/1078-0432.CCR-09-0264
AI Summary: OriGene’s TSC-22 cDNA plasmid was used to overexpress TSC-22 in prostate cancer cell lines, enabling the authors to demonstrate that TSC-22 enhances apoptosis and inhibits tumor growth following IGF-I receptor inhibition.
FigureFigure
Showing 1-1 of 1 papers.
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