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Atp7a Rat shRNA Plasmid (Locus ID 24941)

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SKU
TL711714
Atp7a - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 24941
Synonyms Mnk
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Atp7a - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 24941). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_052803, NM_052803.1, NM_052803.2
UniProt ID P70705
Summary This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. In human, mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. provided by RefSeq, Nov 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells
Ha, Doguer, Collins
Metallomics (2016) 8 (9), 963-972 DOI: 10.1039/c6mt00126b
Cited by 8
AI Summary: In this study, OriGene's Atp7a shRNA lentiviral particles were used to knock down Atp7a expression in rat IEC-6 and human Caco-2 intestinal epithelial cells, enabling the researchers to investigate the role of this copper transporter in regulating iron flux and the expression of iron transport-related genes.
FigureFigure
Copper transport into the secretory pathway is regulated by oxygen in macrophages
White, Kambe, Fulcher et al
J Cell Sci (2009) 122 (Pt 9), 1315-21 DOI: 10.1242/jcs.043216
Cited by 116
AI Summary: OriGene products contributed to this study by providing the mouse ATP7A cDNA (OriGene, MC203526) and mouse ATP7A shRNA (OriGene, TL502431), which were used to manipulate ATP7A expression and investigate its role in copper transport under hypoxic conditions in macrophages.
Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells
Ha, Doguer, Collins
Metallomics (2016)
AI Summary: OriGene’s Atp7a-targeting lentiviral plasmids (Cat. # TL711714) and negative-control plasmids were used to knock down Atp7a expression in IEC-6 cells, enabling the study of its role in iron flux in intestinal epithelial cells.
Snippet: Negative-control and Atp7a-targeting lentiviral plasmids (Cat. # 2 TL711714;OriGene;Rockville, MD) were transfected into IEC-6 cells using the transfection kit 3 provided by the manufacturer. Similar to the shRNA-expressing plasmid approach described 4 ... Cite SaveSaving
Showing 1-3 of 3 papers.
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