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Camk2a Rat shRNA Plasmid (Locus ID 25400)

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SKU
TL709530
Camk2a - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "Camk2a or NM_012920"

Specifications
Specifications
Product Data
Locus ID 25400
Synonyms PK2CDD; PKCCD
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Camk2a - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 25400). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_012920, NM_012920.1
UniProt ID P11275
Summary Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma
Vichaikul, Gurrea-Rubio, Amin et al
JCI Insight (2022) 7 (9) DOI: 10.1172/jci.insight.150871
Cited by 27
AI Summary: OriGene’s CAMK2A expression vector and the PCMV6-XL6 control vector were used to overexpress and control for CAMK2A in patient-derived fibroblasts, enabling the study of calcium signaling in the anti-fibrotic effects of BET inhibition in scleroderma models.
Snippet: …CAMK2A in dcSSc fibroblasts was overexpressed using CAMK2A vectors from OriGene. CAMK2A vector (0.1 μg/mL) was mixed with Lipofectamine 2000 (Invitrogen) and then added to culture medium. … PCMV6-XL6 vector (OriGene) w;- using CAMK2A vectors from Origene. 0.1 μg/ml of CAMK2A vector was PCMV6-XL6 vector (Origene) was used as a negative control. …
Showing 1-1 of 1 papers.
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