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Fbxo46 Rat shRNA Plasmid (Locus ID 292686)

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SKU
TL702960
Fbxo46 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 292686
Synonyms MGC114545
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Fbxo46 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 292686). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001025642, NM_001025642.1, BC098945
UniProt ID Q4KLY2
Summary Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence
Choppara, Ganga, Manne et al
J. Biol. Chem. (2018) 293 (42), 16291-16306 DOI: 10.1074/jbc.RA118.005354
AI Summary: OriGene contributed to this study by providing the FBXO46 plasmid, which was used to investigate the role of FBXO46 in regulating FBXO31 degradation and cellular senescence.
Snippet: We re - cloned FBXO31 in the p3XFLAG - Myc -CMV -26 vector (Sigma) by using the restriction sites of EcoRI and HindIII. Serial N - terminal deletion mutants of FBXO31 were generated in the 3X FLAG 26 vector using the EcoRI and HindIII sites. FBXO46 plasmid was obtained from Origene
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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