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Jph4 Rat shRNA Plasmid (Locus ID 445271)

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SKU
TL700489
Jph4 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 445271
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Jph4 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 445271). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001003711, NM_001003711.1, BC160922
UniProt ID Q69FB3
Summary Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability
Sahu, Wazen, Colarusso et al
Cell Rep (2019) 28 (9), 2427-2442.e6 DOI: 10.1016/j.celrep.2019.07.075
AI Summary: OriGene’s GFP-tagged JPH3-shRNA (Cat. No. TL705996) and JPH4-shRNA (Cat. No. TL700489) were used to downregulate JPH3 and JPH4 expression in cultured hippocampal neurons, enabling the study to demonstrate the role of these proteins in maintaining the Cav1-RyR2-KCa3.1 complex that regulates neuronal excitability.
Snippet: Skip to article;Cultured hippocampal neurons from Sprague-Dawley rat pups were transfected with 0.75 μg each of GFP tagged JPH3-shRNA (Origene, USA;Cat. … TL705996) and JPH4-shRNA (Origene;Cat. … TL700489) on DIV 7 using lipofectamine 2000 (Thermo Scientific). 48-72 hr after transfection cells were fixed and tested for JPH-3&4 immunolabeling. …
Showing 1-1 of 1 papers.
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