Usp19 Mouse shRNA Plasmid (Locus ID 71472)
Specifications
| Product Data | |
| Locus ID | 71472 |
|---|---|
| Synonyms | 8430421I07Rik; AI047774; Zmynd9 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Usp19 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 71472). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC060613, NM_001168371, NM_001168372, NM_001168373, NM_027804, NM_145407, NM_027804.2, NM_027804.4, NM_001168371.1, NM_001168371.2, NM_001168372.1, NM_001168372.2, NM_001168373.1, NM_001168373.2, NM_145407.1, NM_145407.2, NM_145407.3, BC006916, BC046824 |
| UniProt ID | Q3UJD6 |
| Summary | Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains (By similarity). Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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