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S1pr1 Mouse shRNA Plasmid (Locus ID 13609)

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SKU
TL516557
S1pr1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 13609
Synonyms AI849002; Edg1; Lpb1; S; S1; S1p; S1p1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components S1pr1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 13609). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC049094, BC051023, NM_007901, NM_007901.1, NM_007901.2, NM_007901.3, NM_007901.4, NM_007901.5
UniProt ID O08530
Summary This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. provided by RefSeq, Jan 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

S1P-S1PR1 signaling impairs CD8+ T cell metabolism and effector function in tumors
Basak, Ghosh, Gautam et al
EMBO Rep (2026)
Cited by 1
AI Summary: OriGene contributed to this study by providing the Eif2ak3 Mouse shRNA Plasmid (TL510962) and the S1pr1 Mouse shRNA Plasmid (TL516557), which were used for genetic knockdown experiments to investigate the role of S1PR1 signaling in CD8⁺ T cell function within tumors.
Snippet: pMD2.G Addgene 12259 Eif2ak3 Mouse shRNA Plasmid (Locus ID 13666, Vector: pGFP-C-shLenti) Origene TL510962 S1pr1 Mouse shRNA Plasmid (Locus ID 13609, Vector: pGFP-C-shLenti) Origene TL516557
Showing 1-1 of 1 papers.
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