Gpt2 Mouse shRNA Plasmid (Locus ID 108682)
SKU
TL515930
Gpt2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 108682 |
|---|---|
| Synonyms | 4631422C05Rik; ALT2; AU014768; AU041193; C87201 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Gpt2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 108682). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC034219, NM_173866, NM_173866.1, NM_173866.2, NM_173866.3 |
| UniProt ID | Q8BGT5 |
| Summary | Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
Hao, Samuels, Li et al
Nat Commun (2016) 7, 11971 DOI: 10.1038/ncomms11971
Hao, Samuels, Li et al
Nat Commun (2016) 7, 11971 DOI: 10.1038/ncomms11971
Cited by 304
AI Summary: In this study, OriGene products such as PIK3CA expression plasmids and shRNA lentiviral particles were used to manipulate gene expression and investigate how PIK3CA mutations reprogram glutamine metabolism in colorectal cancer cells.
Snippet: This study, however, revealed a novel p110α–PDK1–RSK2–ATF4–GPT2 pathway that regulates glutamine metabolism. … While our previous studies showed that AKT signalling drives metastasis of PIK3CA mutant tumours39, here we propose the p110α–PDK1–RSK2–ATF4–GPT2 signaling axis reprogrammes glutamine metabolism that is required to generate energy and metabolites to sustain rapid growth in PIK3CA mutant tumours
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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