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Sox2 Mouse shRNA Plasmid (Locus ID 20674)

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SKU
TL515613
Sox2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "Sox2 or NM_011443"

Specifications
Specifications
Product Data
Locus ID 20674
Synonyms lc; lcc; Sox; Sox-2; ys; ysb
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Sox2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 20674). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC057574, NM_011443, NM_011443.1, NM_011443.2, NM_011443.3, NM_011443.4, BM938133
UniProt ID P48432
Summary This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells
Ooki, Del Carmen Rodriguez Pena, Marchionni et al
Cancer Res. (2017)
AI Summary: In this study, OriGene’s SOX2 and YAP1 shRNA pGFP-C-shLenti Vectors, along with the non-effective 29-mer scrambled shRNA pGFP-C-shLenti Vector as a control, were used to specifically knock down SOX2 and YAP1 gene expression to investigate their roles in regulating cancer stem-like cells in urothelial carcinoma.
Snippet: SOX2 or YAP1 shRNA pGFP-C-shLenti Vector (SOX2-sh or YAP1-sh) was used for the knockdown of the gene expression (Origene). Non-effective 29-mer scrambled shRNA pGFP-C-shLenti Vector (Origene) was used as a control (SOX2- or YAP1-Ctrl)
Showing 1-1 of 1 papers.
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