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Ddr2 Mouse shRNA Plasmid (Locus ID 18214)

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SKU
TL515586
Ddr2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 18214
Synonyms AW495251; Ntrkr3; tyro10
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ddr2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 18214). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_022563, NM_022563.1, NM_022563.2, BC138826, BC138827
UniProt ID Q62371
Summary Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1
Xie, Lin, Ye et al
J. Exp. Clin. Cancer Res. (2015) 34 (1), 101 DOI: 10.1186/s13046-015-0218-6
Cited by 101
AI Summary: OriGene products contributed to this study by providing the DDR2 expressing plasmid (pCMV6-XL6), DDR2 shRNA, and scrambled shRNA vector (pRS), which were used to manipulate DDR2 expression and investigate its role in hepatocellular carcinoma cell invasion and signaling pathways.
Snippet: Expressing plasmids and RNAi transfection. The DDR2 expressing plasmid and its empty plasmid pCMV6-XL6 were both obtained from Origene Technologies Inc. ... The DDR2 shRNA and scrambled shRNA vector pRS were also purchased from Origene Technologies ... Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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