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Notch3 Mouse shRNA Plasmid (Locus ID 18131)

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SKU
TL515445
Notch3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 18131
Synonyms AW229011; hpbk; N3
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Notch3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 18131). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_008716, NM_008716.1, NM_008716.2, BC172738, NM_008716.3
UniProt ID Q61982
Summary Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord
Rusanescu, Mao
J. Cell. Mol. Med. (2014)
Cited by 37
AI Summary: OriGene's 29 bp Notch3 shRNA plasmids were used to generate Neuro2a-N3RNAi cell lines, enabling the study of Notch3's role in neuronal differentiation and maturation in the adult spinal cord.
Snippet: 1663-2318). Neuro2a-N3RNAi cell lines were derived from Neuro-2a by combined transfection of four plasmids expressing four different 29 bp Notch3 shRNAs (Origene Technologies, Rockville, MD, USA). Positive colonies ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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