Tnf Mouse shRNA Plasmid (Locus ID 21926)
SKU
TL515379
Tnf - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 21926 |
|---|---|
| Synonyms | DI; DIF; Tn; TNF-; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfs; Tnfsf1a; TNFSF2; Tnlg1f |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Tnf - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 21926). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC117057, NM_001278601, NM_013693, NM_013693.1, NM_013693.2, NM_013693.3, NM_001278601.1, BC137720 |
| UniProt ID | P06804 |
| Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jun 2013 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Improved insulin sensitivity in obese-diabetic mice via chitosan Nanomicelles mediated silencing of pro-inflammatory Adipocytokines
Sharma, Arora, Banerjee et al
Nanomedicine (2021) 33, 102357 DOI: 10.1016/j.nano.2020.102357
Sharma, Arora, Banerjee et al
Nanomedicine (2021) 33, 102357 DOI: 10.1016/j.nano.2020.102357
Cited by 25
AI Summary: OriGene contributed to this study by providing plasmids encoding shRNA targeting TNFα and MCP-1 (from OriGene Technologies Inc.), which were used to silence pro-inflammatory adipocytokines and improve insulin sensitivity in obese-diabetic mice.
Snippet: Skip to article;Four unique plasmids encoding shRNA directed towardeach adipocytokine (TNFαor MCP-1) were acquired fromOrigene (Origene Technologies Inc., Rockville, MD, USA)and the constructs showing maximum downregulation wereused for all further analyses
Showing 1-1 of 1 papers.
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