G3bp1 Mouse shRNA Plasmid (Locus ID 27041)
SKU
TL515376
G3bp1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 27041 |
|---|---|
| Synonyms | AI849976; B430204O07; C87777; G3bp; mKIAA4115 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | G3bp1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 27041). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC021156, NM_013716, NM_013716.1, NM_013716.2 |
| UniProt ID | P97855 |
| Summary | ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3' UTR (PubMed:11604510).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy
He, Yang, Abdellatif et al
PLoS ONE (2015) 10 (12), e0145112 DOI: 10.1371/journal.pone.0145112
He, Yang, Abdellatif et al
PLoS ONE (2015) 10 (12), e0145112 DOI: 10.1371/journal.pone.0145112
Cited by 35
AI Summary: OriGene contributed to this study by providing the human G3BP1 cDNA (product SC127200), which was used to generate recombinant adenovirus for overexpression experiments investigating G3BP1's role in microRNA-1 processing during cardiac hypertrophy.
Snippet: control for all adenoviral microRNA constructs. G3BP1: human cDNA was purchased from origene (SC127200) and cloned into recombinant adenovirus under CMV promoter. shRNA against G3bp1 (siG3bp1): hairpin forming ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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