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Ar Mouse shRNA Plasmid (Locus ID 11835)

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SKU
TL514763
Ar - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Ar or NM_013476"

Specifications
Specifications
Product Data
Locus ID 11835
Synonyms AW320017; Tfm
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ar - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 11835). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_013476, NM_013476.1, NM_013476.2, NM_013476.3, NM_013476.4, BC148496, BC153098
UniProt ID P19091
Summary This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. provided by RefSeq, May 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
Pydi, Jain, Tung et al
Nat Commun (2019) 10 (1), 2936 DOI: 10.1038/s41467-019-11003-4
AI Summary: OriGene’s mouse β3-adrenergic receptor expression construct (pCMV6 vector) was used to study β3-AR signaling in cells, enabling the authors to elucidate the regulatory role of β-arrestin-2 in adipocyte function and metabolism.
Snippet: β2-AR (vector backbone: pcDNA 3.1) was kindly provided by Dr. Vsevolod Gurevich (Vanderbilt Univesity). The expression construct encoding the mouse β3-AR (vector backbone: pCMV6) was purchased from OriGene Technologies Inc. Six hour after transfections, 1 × 105 cells were plated in collagen-coated 24-well plates. Cells were allowed to grow for 48 h and then used for experiments. BODY COM
FigureFigureFigure
Showing 1-1 of 1 papers.
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