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Ccnc Mouse shRNA Plasmid (Locus ID 51813)

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SKU
TL514464
Ccnc - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 51813
Synonyms AI451004; AU020987; CG1C
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ccnc - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 51813). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC003344, BC029211, BC120649, BC120677, NM_001122982, NM_001290420, NM_001290422, NM_016746, NM_016746.1, NM_016746.2, NM_016746.3, NM_016746.4, NM_001122982.1, NM_001122982.2, NM_001290420.1, NM_001290422.1, BC037689, BC062376, BC087544, BC100396
UniProt ID Q62447
Summary Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes
He, Ebarasi, Zhao et al
J Am Soc Nephrol (2014) 25 (12), 2764-77 DOI: 10.1681/ASN.2012080823
AI Summary: In this study, OriGene products—specifically the human LMX1B (RC206139) and FOXC2 (RC211545) expression plasmids—were used for gene overexpression experiments to investigate how these transcription factors regulate podocin (NPHS2) expression in podocytes.
Showing 1-1 of 1 papers.
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