Mcam Mouse shRNA Plasmid (Locus ID 84004)
SKU
TL514377
Mcam - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 84004 |
|---|---|
| Synonyms | 1-gicerin; AV025631; CD146; CD149; Muc18; s-endo; s-gicerin |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Mcam - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 84004). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC026985, NM_023061, NM_001359530, NM_023061.1, NM_023061.2 |
| UniProt ID | Q8R2Y2 |
| Summary | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
Balcioglu, Gates, Freeman et al
NPJ Breast Cancer (2024) 10 (1), 80 DOI: 10.1038/s41523-024-00687-7
Balcioglu, Gates, Freeman et al
NPJ Breast Cancer (2024) 10 (1), 80 DOI: 10.1038/s41523-024-00687-7
Cited by 5
AI Summary: OriGene products, including the mouse Mcam shRNA lentiviral plasmid (Cat # TL514377), a scrambled shControl, and a custom shRNA-resistant mouse Mcam construct (pLenti-C-mCFP-P2A-BSD, # PS100107), were used in this study to manipulate Mcam expression and investigate its role in maintaining the luminal progenitor-like state in breast cancer cells.
Snippet: smids were obtained from OriGene Technologies, Inc. (Rockville, MD), including the mouse Mcam shRNA lentiviral plasmid (Cat # TL514377), a scrambled shControl, and a custom shRNA-resistant (via silent-mutation) mouse Mcam construct subcloned into a lentiviral gene expression vector (pLenti-C-mCFP-P2A-BSD), (# PS100107). Comple
Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
Balcioglu, Gates, Freeman et al
bioRxiv (2023)
Balcioglu, Gates, Freeman et al
bioRxiv (2023)
Cited by 2
Snippet: Viral vector plasmids were obtained from OriGene Technologies, Inc. (Rockville, MD), including the mouse Mcam shRNA lentiviral plasmid (Cat # TL514377), a scrambled shControl, and a custom shRNA-resistant (via silent-mutation) mouse Mcam construct subcloned into a lentiviral gene expression vector (pLenti-C-mCFP-P2A-BSD), (# PS100107). Completed vectors were sequenced confirmed
Showing 1-2 of 2 papers.
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