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Tead1 Mouse shRNA Plasmid (Locus ID 21676)

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SKU
TL513813
Tead1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 21676
Synonyms 2610024B07Rik; B230114H05Rik; Gtrgeo5; mTEF-1; Tcf13; TEAD-1; TEF-1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Tead1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 21676). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC060138, NM_001166584, NM_001166585, NM_009346, NM_001166585.1, NM_009346.1, NM_009346.3, NM_001166584.1, BC027158, BC049153, BC052021, BM214769, NM_175559
Summary Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression
Shen, Li, Zhu et al
J. Exp. Clin. Cancer Res. (2020) 39 (1), 36 DOI: 10.1186/s13046-020-1542-z
Cited by 108
AI Summary: OriGene products, including the YAP1 Mouse shRNA Plasmid (CAT#: TG502437), TEAD1 Mouse shRNA Plasmid (CAT#: TL513813), and shRNA vector (CAT#: TR30007), were used in this study to manipulate gene expression in fibroblasts, enabling the investigation of YAP1 and TEAD1 roles in converting normal fibroblasts into cancer-associated fibroblasts that promote prostate cancer progression.
Snippet: The following shRNA plasmids were used in this study for in vitro transfection: YAP1 Mouse shRNA Plasmid, CAT#: TG502437, Origene;TEAD1 Mouse shRNA Plasmid, CAT#: TL513813, Origene;shRNA vector, CAT#: TR30007, Origene;YAP1 Mouse Tagged ORF;- The following shRNA plasmids were used in this study for in vitro transfection: YAP1 Mouse shRNA Plasmid, CAT#: TG502437, Origene
FigureFigureFigure
Showing 1-1 of 1 papers.
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