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Lamtor1 Mouse shRNA Plasmid (Locus ID 66508)

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SKU
TL513263
Lamtor1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
4 Weeks*

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Specifications
Specifications
Product Data
Locus ID 66508
Synonyms 2400001E08Rik; p18; Pdro
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Lamtor1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 66508). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC020142, BC092062, BC096412, BC126973, NM_025605, NM_025605.1, NM_025605.2, NM_025605.3
UniProt ID Q9CQ22
Summary As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1 pathway to ameliorate lipid accumulations in MAFLD
Jang, Ko, Lee et al
Autophagy (2025)
Cited by 17
AI Summary: In this study, OriGene’s shLAMTOR1 plasmid (TL513263) and MYC-DDK-tagged LAMTOR1 clone (MR201262) were used to manipulate LAMTOR1 expression in cells, enabling the researchers to demonstrate the role of LAMTOR1 in autophagy regulation and its contribution to the therapeutic effects of acacetin in MAFLD.
Snippet: …For gene knockdown or overexpression studies, cells were transfected with the shLAMTOR1 plasmid (OriGene, TL513263) or LAMTOR1 (MYC-DDK-tagged) clone (OriGene, MR201262) using Lipofectamine 3000 according to the manufacturer’s instructions. …
Showing 1-1 of 1 papers.
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