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Foxc1 Mouse shRNA Plasmid (Locus ID 17300)

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SKU
TL513221
Foxc1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 17300
Synonyms ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Foxc1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 17300). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC052011, NM_008592, NM_008592.1, NM_008592.2, BC027689
UniProt ID Q61572
Summary DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:9635428, PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:11562355, PubMed:18187037, PubMed:19668217, PubMed:22493429, PubMed:24590069, PubMed:25808752, PubMed:28223138). Acts either as a transcriptional activator or repressor (PubMed:28223138). Binds to the consensus binding site 5'-G/CA/TAAAT/CAAA/C-3' in promoter of target genes (PubMed:25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed:25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed:25808752). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed:28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed:18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:10704385, PubMed:11562355, PubMed:15196959). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed:24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (PubMed:22171010). May function as a tumor suppressor (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Oct4-dependent FoxC1 Activation Improves the Survival and Neovascularization of Mesenchymal Stem Cells under Myocardial Ischemia
Ji, Chen, Cui et al
Stem Cell Research & Therapy (2021) 12 (1) DOI: 10.1186/s13287-021-02553-w
Cited by 12
AI Summary: In this study, OriGene products Lenti-FoxC1 shRNA (TL513221V) and Lenti-Ang1 shRNA (TR711949) were used to specifically knock down FoxC1 and Ang1 gene expression, enabling the researchers to investigate their roles in mesenchymal stem cell survival and neovascularization under ischemic conditions.
Snippet: density of 5 × 104 per cm2 culture and infected with Lenti-FoxC1 shRNA (TL513221V, OriGene Technologies), Lenti 7998, GenePharma), Lenti-Ang1 shRNA (TR711949, OriGene Technologies), Lenti-bFGF shRNA (TR710311, OriGene
EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers
Zheng, Li, Yi et al
Acta Pharmacol Sin (2020)
Cited by 21
AI Summary: OriGene’s EZH2 expression plasmids and empty vector were used to transfect HCC1806 breast cancer cells, enabling the study to assess how EZH2 regulates FOXC1 expression via H3K27me3 modification.
Snippet: HCC1806 cells, which have low EZH2 expression, were cultured in 60-mm dishes to 75%–85% confluence for 24 h before transfection. Cells were then transfected with EZH2 expression plasmids (OriGene, Rockville, MD, USA) or an empty vector (OriGene,
WB IHC
FOXC1 promotes melanoma by activating MST1R/PI3K/AKT
Wang, Li, Liu et al
Oncotarget (2016) 7 (51), 84375-84387 DOI: 10.18632/oncotarget.11224
Snippet: M14, M15, M219 and Wp-0614 cells were plated in 60 dishes at 80% confluence before transfection 24h. FOXC1-myc-flag plasmid (Origene, Rockville, MD) and FOXC1 shRNAs (Sigma-Aldrich, St.Louis, MO) were stably transfected into M15, M219, M14 and Wp-0614 using Lipofectamine 3000 transfection reagent (Invitrogen, Grand Island, NY) for 24 h
FigureFigureFigure
Showing 1-3 of 3 papers.
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