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Rbpj Mouse shRNA Plasmid (Locus ID 19664)

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SKU
TL512813
Rbpj - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 19664
Synonyms AI843960; CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa; RBP-Jkappa; RBPjk; Rbpsuh
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Rbpj - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19664). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC051387, NM_001080927, NM_001080928, NM_001277116, NM_009035, NM_001359152, NM_001080927.1, NM_001080927.2, NM_009035.1, NM_009035.3, NM_009035.4, NM_009035.5, NM_001080928.1, NM_001277116.1, BC035299
UniProt ID P31266
Summary Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

DNA methylation mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation
Xiao, Fang, Liu et al
J Clin Invest (2023)
AI Summary: OriGene products LentiDnmt3b (#MR225598L4V) and Lenti-shRbpjk (#TL512813V) were used to overexpress Dnmt3b and knockdown Rbpjk, respectively, in progenitor cells to investigate their roles in bone regeneration under inflammatory conditions.
Snippet: …After recovery, LentiDnmt3b (MOI=10;Origene, #MR225598L4V) and Lenti-shRbpjk (MOI=10;Origene, #TL512813V) were used to infect Adeno virus treated Ikk2caf/+ PPCs to overexpress Dnmt3b and knockdown Rbpjk in cells, respectively
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a
Xiao, Liu, Zhang et al
Nat Commun (2018) 9 (1), 2865 DOI: 10.1038/s41467-018-05209-1
AI Summary: OriGene’s lentiviral vectors encoding mouse Rbpj shRNA (TL512813) and scrambled Rbpj shRNA (TL512813) were used to investigate the role of Rbpj in the direct reprogramming of fibroblasts into neural stem cells by Ptf1a.
Snippet: pand and passage cells derived from each colony. RNA knockdown and Notch signaling inhibition For Rbpj knockdown assay, we purchased lentiviral vectors encoding mouse Rbpj short hairpin RNA (shRNA) (OriGene, TL512813) or scrambled Rbpj shRNA (OriGene, TL512813). MEF cells were infected with a mixture of Ptf1a and Rbpj shRNA viruses for the knockdown group, and with a mixture of Ptf1a and scramble
FigureFigureFigure
Showing 1-2 of 2 papers.
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