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Agrn Mouse shRNA Plasmid (Locus ID 11603)

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SKU
TL512313
Agrn - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 11603
Synonyms Agrin; nmf380
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Agrn - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 11603). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_021604, NM_021604.1, NM_021604.2, NM_021604.3, BC150703, BC004020, BC028992, BC043318, BC058651, BC059259, BC064021, BC094010, NM_001369026, NM_001369027
Summary Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This transmembrane agrin (TM-agrin) isoform, the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation
Mueller, Stavely, Guyer et al
Stem Cells Transl Med (2024)
Cited by 10
AI Summary: OriGene products, specifically the shRNA lentiviral particles targeting agrin (CAT#: TL512313V) and the control shRNA with a GFP reporter (CAT#: TR30021V), were used in this study to inhibit agrin expression in enteric neural stem cells, enabling the researchers to demonstrate that agrin inhibition enhances cell migration after colonic transplantation.
Snippet: shRNA and a GFP reporter (purchased from Origene;CAT#: TL512313V, and shRNA with a GFP reporter (purchased from Origene;CAT# TR30021V, and expanded and
Showing 1-1 of 1 papers.
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