Hc Mouse shRNA Plasmid (Locus ID 15139)
SKU
TL511576
Hc - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 15139 |
|---|---|
| Synonyms | C5; C5a; He |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Hc - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 15139). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_010406, NM_010406.1, NM_010406.2, BC003963, BC156369, NM_010406.3 |
| UniProt ID | P06684 |
| Summary | This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. provided by RefSeq, Nov 2015 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
MK801 regulates the expression of key osteoarthritis factors in osteoarthritis synovial fibroblasts through complement C5
Huang, Feng, Zhu et al
Res Vet Sci (2021) 136, 377-384 DOI: 10.1016/j.rvsc.2021.03.003
Huang, Feng, Zhu et al
Res Vet Sci (2021) 136, 377-384 DOI: 10.1016/j.rvsc.2021.03.003
Cited by 2
AI Summary: In this study, OriGene's mouse C5 siRNA (SR420963) and mouse C5 overexpression plasmid (MR226017) were used to modulate complement C5 expression in osteoarthritis synovial fibroblasts, enabling the authors to demonstrate the role of C5 in mediating MK801’s effects on inflammatory and osteoarthritis-related factors.
MK801 regulates the expression of key osteoarthritis factors in osteoarthritis synovial fibroblasts through complement C5
Huang, Feng, Zhu et al
Research in Veterinary Science (2021) 136, 377-384 DOI: 10.1016/j.rvsc.2021.03.003
Huang, Feng, Zhu et al
Research in Veterinary Science (2021) 136, 377-384 DOI: 10.1016/j.rvsc.2021.03.003
Cited by 2
AI Summary: OriGene products, specifically the C5 shRNA vector (CAT#: TL511576) and C5 overexpression vector (CAT#: MR225064), were used to manipulate complement C5 expression in osteoarthritis synovial fibroblasts, enabling the study of its role in the regulation of osteoarthritis marker factors by MK801.
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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