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Ido1 Mouse shRNA Plasmid (Locus ID 15930)

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SKU
TL511273
Ido1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "Ido1 or NM_001293690"

Specifications
Specifications
Product Data
Locus ID 15930
Synonyms Ido; Indo
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ido1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 15930). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC049931, NM_001293690, NM_008324, NM_008324.1, NM_008324.2, NM_001293690.1
UniProt ID P28776
Summary Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (Ref. 3).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation
Liu, Liang, Dong et al
Cancer Cell (2018) 33 (3), 480-494.e7 DOI: 10.1016/j.ccell.2018.02.005
AI Summary: OriGene products, including pGFP-C-shLenti-shIDO1, pGFP-C-shLenti-shSLC1A5, pGFP-V-RS-shPAT4, pGFP-V-RS-shSLC7A8, and pCMV6-Entry-DDKSLC1A5, were used in this study to manipulate gene expression related to kynurenine transport and metabolism, enabling the authors to investigate mechanisms of PD-1 upregulation in CD8+ T cells.
Snippet: pGFP-C-shLenti-shIDO1, pGFP-C-shLenti-shSLC1A5, pGFP-V-RS-shPAT4, pGFP-V-RS-shSLC7A8 and pCMV6-Entry-DDKSLC1A5 were purchased from Origene (MD, USA). …
Showing 1-1 of 1 papers.
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