Smo Mouse shRNA Plasmid (Locus ID 319757)
SKU
TL510788
Smo - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 319757 |
|---|---|
| Synonyms | bnb; E130215L21Rik; Smoh; smoothened |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Smo - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 319757). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC048091, BC096028, NM_176996, NM_176996.1, NM_176996.2, NM_176996.3, NM_176996.4, BC030377 |
| UniProt ID | P56726 |
| Summary | G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models
Ma, Tian, Yu
Med. Sci. Monit. (2017) 23, 1493-1500
Ma, Tian, Yu
Med. Sci. Monit. (2017) 23, 1493-1500
AI Summary: OriGene contributed mouse SMO overexpression lentivirus vectors, shRNA lentivirus vectors, and control vectors, which were used for cell transfection experiments to study the role of SMO in gastric cancer chemotherapy resistance.
Snippet: The total protein amount was measured and normalized by BCA assay. Cell transfection Mouse SMO overexpression lentivirus vector, shRNA lentivi- rus vector, and control vector were purchased from Origene (Rockville, MD, USA). ... All 2 versions Cite SaveSaving
Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
Wang, Peng, Liu et al
BMC Cancer (2015) 15, 595 DOI: 10.1186/s12885-015-1596-z
Wang, Peng, Liu et al
BMC Cancer (2015) 15, 595 DOI: 10.1186/s12885-015-1596-z
Cited by 35
AI Summary: In this study, OriGene products—including the human GLI1 expression plasmid (RC209875) and GLI1 shRNA plasmids (TL313590)—were used to manipulate and analyze Hedgehog pathway activity, helping to elucidate berberine’s inhibitory effects on this cancer-related signaling pathway.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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