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Mcm6 Mouse shRNA Plasmid (Locus ID 17219)

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SKU
TL510769
Mcm6 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 17219
Synonyms ASP-l1; D1Wsu22e; Mcmd6
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Mcm6 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 17219). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC050886, BC057584, NM_001313695, NM_008567, NM_008567.1, NM_008567.2, BC051658
UniProt ID P97311
Summary Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Flach, Bakker, Mohrin et al
Nature (2014)
Cited by 654
AI Summary: OriGene’s pGFP-C-shLenti vectors containing shRNA targeting murine Mcm4 (TL514127), Mcm6 (TL510769), and non-targeting scrambled shRNA (TR30021) were used to manipulate gene expression in haematopoietic stem cells, enabling the study of replication stress and its role in ageing-related functional decline.
Snippet: … Briefly, pGFP-C-shLenti vectors containing shRNA targeting murine Mcm4 (TL514127) and Mcm6 (TL510769) genes or non-targeting scrambled shRNA (TR30021) were purchased from Origene. …
Showing 1-1 of 1 papers.
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