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Esr1 Mouse shRNA Plasmid (Locus ID 13982)

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SKU
TL510613
Esr1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Esr1 or NM_001302531"

Specifications
Specifications
Product Data
Locus ID 13982
Synonyms E; ER; ER-; ER-alpha; ERa; ERalpha; ER[; Es; ESR; Estr; Estra; Nr; Nr3a1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Esr1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 13982). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001302531, NM_001302532, NM_001302533, NM_007956, NR_126357, NM_007956.1, NM_007956.2, NM_007956.3, NM_007956.4, NM_007956.5, NM_001302533.1, NM_001302531.1, NM_001302532.1, BC167246
UniProt ID P19785
Summary This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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17β-estradiol binding to ERα promotes the progression of prolactinoma through estrogen-response element-induced CaBP-9k up-regulation
Liu, Han, Lu et al
Biosci Rep (2020) 40 (1) DOI: 10.1042/BSR20191330
AI Summary: In this study, OriGene’s ERα shRNA (Cat# TG501902) was used to down-regulate ERα expression in GH3 and MMQ cells, helping to demonstrate that E2-induced CaBP-9k up-regulation and prolactinoma progression are dependent on ERα.
FigureFigureFigure
17β-estradiol binding to ERα promotes the progression of prolactinoma through estrogen-response element-induced CaBP-9k up-regulation
Liu, Han, Lu et al
Biosci. Rep. (2020) 40 (1) DOI: 10.1042/BSR20191330
AI Summary: OriGene contributed to this study by providing short hairpin RNAs (shRNAs) targeting ERα (sh-ERα, No. TL510613), CaBP-9k (sh-CaBP-9k, No. TL709169), and negative control vectors (sh-NC), which were used to investigate the roles of these genes in prolactinoma progression.
Snippet: RNA interference Short hairpin RNAs (shRNAs) used to silence ERα (sh-ERα;No. TL510613) or (sh-CaBP-9k, No. TL709169), and the negative control vectors (sh-NC) were purchased from OriGene (Beijing, China). Western;;- RNA interference Short hairpin RNAs (shRNAs) used to silence ERα (sh-ERα
Modulation effects of black-vinegar based supplement against a high-fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy-metabolism effects
Liu, Chou, Li et al
J. Sci. Food Agric. (2020)
Cited by 10
AI Summary: In this study, OriGene’s RXRα antibody was used to assess protein expression changes in liver tissues, helping to elucidate the molecular mechanisms by which black-vinegar based supplements exert antiobesity and lipid-lowering effects in rats fed a high-fat diet.
Snippet: (1:3000 dilution, Santa Cruz Biotechnology Inc., Dallas, Texas, USA), PPARα (1:3000 dilution, Abcam PLC., Cambridge, UL), RXRα (1:3000 dilution, OriGene Technologies, Inc., Rockville, Maryland, USA), CPT1 (1:4000 dilution, Merck Millipore Co.), and UCP2
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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