Prdm1 Mouse shRNA Plasmid (Locus ID 12142)
SKU
TL510199
Prdm1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 12142 |
|---|---|
| Synonyms | b2b1765Clo; Blimp-1; Blimp1; PRDI-BF1; ZNFPR1A1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Prdm1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 12142). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_007548, NM_007548.1, NM_007548.2, NM_007548.3, NM_007548.4, BC129801, BC172658 |
| UniProt ID | Q60636 |
| Summary | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1
Wang, Loh, Chen et al
Mol. Immunol. (2018) 99, 53-65 DOI: 10.1016/j.molimm.2018.04.004
Wang, Loh, Chen et al
Mol. Immunol. (2018) 99, 53-65 DOI: 10.1016/j.molimm.2018.04.004
AI Summary: OriGene products, specifically the Blimp-1 pLenti-shRNA construct (TL510199) and the Lenti-vpak Lentiviral packaging kit, were used to generate lentivirus for Blimp-1 knockdown experiments, enabling the study of Blimp-1’s role in T cell-mediated allograft tolerance.
Snippet: Blimp-1 knockdown was performed using lentivirus produced by cotransfection of HEK293T cells with Blimp-1 pLenti-shRNA construct (TL510199) and the packaging plasmids, protocol as described in the Lenti-vpak Lentiviral packaging kit (OriGene Technologies
Showing 1-1 of 1 papers.
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