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Ppargc1a Mouse shRNA Plasmid (Locus ID 19017)

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SKU
TL509292
Ppargc1a - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "Ppargc1a or NM_008904"

Specifications
Specifications
Product Data
Locus ID 19017
Synonyms A830037N07Rik; Gm11133; Pgc; PGC-1; Pgc-1alpha; Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ppargc1a - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19017). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC066868, NM_008904, NR_027710, NR_132764, NM_008904.1, NM_008904.2
UniProt ID O70343
Summary This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway
Ji, Zheng, Lv et al
Free Radic. Biol. Med. (2015)
Cited by 93
AI Summary: In this study, OriGene's PGC-1α shRNA lentivirus was used to specifically knock down PGC-1α expression in C2C12 myoblasts, helping to elucidate the role of PGC-1α in FGF21-mediated activation of mitochondrial function.
Snippet: YY1 and PGC-1α shRNA lentivirus were purchased from GENECHEM (China) and ORIGENE respectively. Blocking PI3K-AKT pathway. The C2C12 myoblasts were pretreated with 30 µM LY294002 (Sigma) for 2 h and then treated with FGF21 (50 ng/ml). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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