Abi2 Mouse shRNA Plasmid (Locus ID 329165)
SKU
TL508429
Abi2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 329165 |
|---|---|
| Synonyms | 8430425M24Rik; AI839867; C130078H13 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Abi2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 329165). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC056345, BC079545, BC079646, NM_001198570, NM_001198571, NM_198127, NM_198127.1, NM_198127.2, NM_001198571.1, NM_001198570.1, BC056185 |
| UniProt ID | P62484 |
| Summary | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (By similarity). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (By similarity). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (PubMed:15572692). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (PubMed:27605705). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (PubMed:15572692). Also required for nascent adherens junction assembly in epithelial cells (By similarity).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
Qi, Liu, Chao et al
J. Cell Biol. (2020) 219 (9) DOI: 10.1083/jcb.201910041
Qi, Liu, Chao et al
J. Cell Biol. (2020) 219 (9) DOI: 10.1083/jcb.201910041
Cited by 19
AI Summary: OriGene's shRNA vectors targeting mouse Abi1, Abi2, and Nckap1 were used to specifically knock down these genes in embryonic stem cells, enabling the authors to investigate their roles in PTEN-mediated epithelial morphogenesis.
Snippet: The shRNA vectors targeting specifically mouse Abi1, Abi2, Nckap1, and the control scrambled sequences were obtained from OriGene. The effective sequences selected by immunoblot analysis of stably transfected ES cell lines are 59-TCAGAGACC AAGGACGCATTAGTGGAAGT-39 (Abi1), 59-ACTGCGAGAATAACT ACATCCAGTCACCA-39 (Abi2), and 59-ACGCCTTGGTCAGATGA TTGTGGACTATG-39 (Nckap1). …
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
